AntiFold
Antibody-specific inverse folding, fine-tuned from ESM-IF1.
OPIG (Oxford Protein Informatics Group) and collaborators
What it does
Designs antibody sequences for a given Fv backbone. Input: an antibody structure (PDB) with the regions to redesign, e.g. specific CDRs; output: per-position amino-acid probabilities and sampled sequences that keep the fold - the antibody-tuned counterpart to ProteinMPNN.
Commercial use
Commercial use OKLicence as writtenBSD 3-Clause License (code and the released model weights)
The repo LICENSE is BSD 3-Clause, and the README's model section links the weight download alongside an explicit 'License: BSD 3-Clause' line for those weights. One caveat read in the same README: an optional --esm_if1_mode runs ESM-IF1 weights instead, which carry Meta's own terms - check those if you use that flag.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Is commercial use free of charge?
Free for commercial useFree: BSD 3-Clause for both code and weights, no fee.
Price and rights are separate: this panel is about money, the panel above is about permission.
When to use it
Use instead of plain ProteinMPNN whenever the backbone is an antibody: it respects antibody sequence statistics and is the practical tool for CDR resurfacing and affinity-maturation libraries. Runs on CPU.
Facts
- Maker
- OPIG (Oxford Protein Informatics Group) and collaborators
- Cost for commercial use
- Free for commercial use
- Compute
- CPU
- Open weights
- Yes
- Licence
- BSD 3-Clause License (code and the released model weights)
- Official site / repo
- github.com/oxpig/AntiFold
- Paper
- academic.oup.com
- Last verified
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