PRODIGY
Estimates binding affinity of protein-protein complexes from structure.
Bonvin lab, Utrecht University
What it does
Affinity estimate for a protein-protein complex. Input: a complex structure (PDB); output: a predicted binding affinity (dG/Kd estimate) from interfacial contact composition - a structure-based ranking signal, not a measurement.
Commercial use
Commercial use OKLicence as writtenApache License 2.0
Apache-2.0 LICENSE file reported by the GitHub license API for haddocking/prodigy.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Is commercial use free of charge?
Free for commercial useNothing to pay: the licence read at the source grants commercial use with no fee, and the code and weights are public downloads. You still pay for your own compute.
Price and rights are separate: this panel is about money, the panel above is about permission.
When to use it
Fast contact-based ΔG estimate to rank protein-protein complexes. It was fitted on experimental crystal complexes, so predictions on modelled or designed interfaces are rough at best and never a substitute for SPR/BLI.
Facts
- Maker
- Bonvin lab, Utrecht University
- Cost for commercial use
- Free for commercial use
- Category
- Docking and affinity estimation
- Compute
- CPU
- Open weights
- Yes
- Licence
- Apache License 2.0
- Official site / repo
- github.com/haddocking/prodigy
- Paper
- elifesciences.org
- Last verified
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