by Seq2Study

HelixFold3

Baidu's AlphaFold3 reproduction - code non-commercial, commercial use only via the paid server.

Baidu (PaddleHelix team)

What it does

Predicts all-atom biomolecular complexes (proteins, ligands, nucleic acids, ions). Input: a JSON entity list with optional MSAs; output: ranked all-atom complex structures with confidence scores. Built on PaddlePaddle, so it needs that stack rather than PyTorch.

Commercial use

Restricted

Licence as writtenCustom 'Terms of Use Agreement' - non-commercial use only for code and parameters

The helixfold3 LICENSE states the open-source code and derivative works are 'only available for non-commercial use by individuals and non-commercial organizations... or for journalism', and the README repeats that code and model parameters are non-commercial only. The same README says the free version of the HelixFold3 server is non-commercial while 'the paid version offers unrestricted usage, enabling commercial applications' - so commercial use exists, but only as a paid hosted service, not as a self-hosted model.

Some commercial use is possible, but a component, dependency or condition needs a paid licence or carries obligations.

Is commercial use free of charge?

Paid API or hosted service only

Self-hosting commercially is not permitted at any price. Commercial use runs through the paid tier of the hosted HelixFold3 server; the README states the free tier is non-commercial and the paid tier is unrestricted, but does not publish the price.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Mostly of academic or comparative interest. If you need an AlphaFold3-class predictor you can self-host commercially, use Boltz-2, Chai-1 or Protenix instead; HelixFold3 would mean paying for Baidu's server.

Facts

Maker
Baidu (PaddleHelix team)
Cost for commercial use
Paid API or hosted service only
Compute
Heavy GPU
Open weights
Yes
Licence
Custom 'Terms of Use Agreement' - non-commercial use only for code and parameters
Last verified

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