Observed Antibody Space (OAS)

Over a billion annotated antibody repertoire sequences, paired and unpaired.

OPIG, University of Oxford

What it does

Antibody repertoire sequences. Input: a query over studies/species/chains; output: over a billion annotated BCR sequences, paired and unpaired, for training language models and checking whether a CDR looks natural.

Commercial use

Commercial use OK

Licence as writtenCreative Commons Attribution 4.0 International (CC BY 4.0)

The OAS homepage states: 'Please note that the data contained within OAS is available under a CC-BY 4.0 license.'

Proof — pages read on 15 Oct 2026
  1. opig.stats.ox.ac.uk/webapps/oas

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Is commercial use free of charge?

Free for commercial use

Free under CC BY 4.0, including for commercial training runs; attribute OAS and the underlying studies.

Proof — pages read on 15 Oct 2026
  1. opig.stats.ox.ac.uk/webapps/oas

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Use for training or benchmarking antibody language models and for germline/naturalness baselines. Study-level batch effects and uneven donor coverage mean naive frequency statistics mislead.

Facts

Maker
OPIG, University of Oxford
Cost for commercial use
Free for commercial use
Open weights
Yes
Licence
Creative Commons Attribution 4.0 International (CC BY 4.0)
Last verified