by Seq2Study

UniProt

Reference protein sequence and functional annotation database.

UniProt Consortium (EMBL-EBI, SIB, PIR)

What it does

Reference sequences and annotation. Input: accession, gene or text query; output: canonical sequences, isoforms, domains, PTMs and functional annotation - the identity layer for any target you design against.

Commercial use

Commercial use OK

Licence as writtenCreative Commons Attribution 4.0 International (CC BY 4.0)

The UniProt license help page states CC BY 4.0 applies to all copyrightable parts of their databases, with a disclaimer that some data may be covered by patents or other rights.

Proof — pages read on 15 Oct 2026
  1. rest.uniprot.org/help/license
  2. uniprot.org/help/license

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Is commercial use free of charge?

Free for commercial use

Free under CC BY 4.0, bulk downloads included.

Proof — pages read on 15 Oct 2026
  1. uniprot.org/help/license

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Canonical source for target sequences, isoforms, domains and PTM annotation before any design run. Annotation quality varies sharply between reviewed (Swiss-Prot) and unreviewed (TrEMBL) entries.

Facts

Maker
UniProt Consortium (EMBL-EBI, SIB, PIR)
Cost for commercial use
Free for commercial use
Open weights
Yes
Licence
Creative Commons Attribution 4.0 International (CC BY 4.0)
Official site / repo
uniprot.org
Last verified

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