DiffAb
Diffusion model for antigen-specific CDR design and optimisation.
Shitong Luo et al. (academic release)
What it does
Designs or redesigns CDRs against a given antigen. Input: an antibody-antigen complex structure (or a docked framework) and the CDR to vary; output: sampled CDR sequence-structure pairs, supporting de novo design, sequence-structure co-design and optimisation of an existing antibody.
Commercial use
Commercial use OKLicence as writtenApache License 2.0
Apache-2.0 LICENSE in the repo; the trained checkpoints are distributed from the same repository with no separate terms. It does depend on antibody structure tooling, which you should licence-check separately.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Is commercial use free of charge?
Free for commercial useFree: Apache-2.0 code and checkpoints, no fee.
Price and rights are separate: this panel is about money, the panel above is about permission.
When to use it
A well-known, easy-to-run baseline for CDR redesign when you already have a complex structure - good for optimisation and for sanity-checking newer tools. It needs a starting complex; it will not find an epitope for you.
Facts
- Maker
- Shitong Luo et al. (academic release)
- Cost for commercial use
- Free for commercial use
- Category
- Antibody-specific design
- Compute
- Single GPU
- Open weights
- Yes
- Licence
- Apache License 2.0
- Official site / repo
- github.com/luost26/diffab
- Paper
- biorxiv.org
- Last verified
Get told when a licence changes
Licences on these tools do change. One short email when a status flips or a tool is added. No other use of your address.