by Seq2Study

RFantibody

Pipeline for structure-based de novo antibody and nanobody design.

Institute for Protein Design, University of Washington (RosettaCommons)

What it does

Designs antibody/nanobody CDR loops onto a real framework. Input: target PDB + epitope hotspots + a VHH or scFv framework; output: designed CDR backbones, then sequences via its ProteinMPNN step and a filter pass with RoseTTAFold2 antibody scoring.

Commercial use

Unverified

Licence as writtenMIT License

The repo LICENSE is MIT, which covers the code. The README downloads model weights via include/download_weights.sh but states no separate license for those weights, so weight terms are unverified.

We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.

Is commercial use free of charge?

Free for commercial use

No fee is charged for the code (MIT) or the weight download script, but the weights carry no licence of their own, so the right to use them commercially is a separate, unresolved question from the price.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Use when you specifically need CDR-loop design on a real framework (VHH or scFv) rather than generic binders. Published experimental hit rates are low and affinities are typically weak starting points needing affinity maturation.

Facts

Maker
Institute for Protein Design, University of Washington (RosettaCommons)
Cost for commercial use
Free for commercial use
Compute
Single GPU
Open weights
Yes
Licence
MIT License
Last verified

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