by Seq2Study

ESM3

Generative multimodal protein model reasoning jointly over sequence, structure and function.

EvolutionaryScale (repository now copyright Chan Zuckerberg Biohub)

What it does

Generates and edits proteins across three tracks at once. Input: any partial specification - sequence, backbone coordinates, secondary structure, SASA or function keywords, with the rest masked; output: the completed sequence and/or structure. Used for prompted generation and scaffolding rather than plain embedding extraction.

Commercial use

Commercial use OK

Licence as writtenMIT License (LICENSE.md, Copyright 2026 Chan Zuckerberg Biohub, Inc.)

The repository LICENSE.md is MIT and the README's Licenses section states 'These models are available under the MIT license' - a change from the earlier non-commercial Cambrian open licence. Larger checkpoints remain behind a hosted API; the open ones are the MIT-licensed download.

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Is commercial use free of charge?

Free for commercial use

Free for the open checkpoints under MIT. The vendor's hosted API for the larger models is a separate paid service you are not required to use.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Use when you want prompted generation conditioned on structure or function, not just embeddings - that is what separates it from ESM-2 and ESM C. Open checkpoint is the small one; the headline results used much larger models served over the API.

Facts

Maker
EvolutionaryScale (repository now copyright Chan Zuckerberg Biohub)
Cost for commercial use
Free for commercial use
Compute
Heavy GPU
Open weights
Yes
Licence
MIT License (LICENSE.md, Copyright 2026 Chan Zuckerberg Biohub, Inc.)
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