ProtGPT2

GPT-2-style generative model that writes de novo protein sequences.

Noelia Ferruz et al.

What it does

Generates novel protein sequences unconditionally or from a seed. Input: an optional sequence prefix and sampling parameters; output: new sequences in natural-protein-like space, plus perplexity scores. A sequence-only generator: it says nothing about structure, so fold it afterwards.

Commercial use

Commercial use OK

Licence as writtenApache License 2.0 (as declared on the model card)

The Hugging Face model card metadata declares apache-2.0 for the published weights, and the model is ungated. Verified against the Hugging Face model API.

Proof — pages read on 15 Oct 2026
  1. huggingface.co/nferruz/ProtGPT2

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Is commercial use free of charge?

Free for commercial use

Free: Apache-2.0 weights, public download, no fee.

Proof — pages read on 15 Oct 2026
  1. huggingface.co/nferruz/ProtGPT2

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Cheap sequence-space exploration and baseline generation, especially for scaffolds or linkers. Outputs need structure prediction and filtering; it has no notion of a target.

Facts

Maker
Noelia Ferruz et al.
Cost for commercial use
Free for commercial use
Compute
Single GPU
Open weights
Yes
Licence
Apache License 2.0 (as declared on the model card)
Last verified