by Seq2Study

ProGen3

Profluent's sparse protein language model family - code open, weights non-commercial.

Profluent Bio

What it does

Generates and scores protein sequences at scale. Input: a prompt (family/function tags or a partial sequence) for generation, or sequences for scoring; output: generated sequences, or log-likelihood fitness scores used to rank variants. Ships as a CLI for scoring and generation.

Commercial use

Not for commercial use

Licence as writtenApache License 2.0 (code, LICENSE-CODE); CC BY-NC-SA 4.0 (model weights)

The README states up front that 'the model weights are released under a non-commercial usage license', and its LICENSE section splits them: Apache-2.0 for the code in LICENSE-CODE, CC BY-NC-SA 4.0 for the weights. The Hugging Face model card metadata also declares cc-by-nc-sa-4.0. The code being Apache-2.0 does not help: without the weights there is no model.

The licence limits use to non-commercial purposes; a company needs a separate agreement.

Is commercial use free of charge?

No commercial option at any price

No fee, but also no commercial grant: CC BY-NC-SA 4.0 excludes commercial use and Profluent publishes no commercial licence price for the weights.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Academic sequence generation and variant scoring at scale. Commercially, use ESM-2/ESM C or ProtGPT2, all of which are permissive.

Facts

Maker
Profluent Bio
Cost for commercial use
No commercial option at any price
Compute
Heavy GPU
Open weights
Yes
Licence
Apache License 2.0 (code, LICENSE-CODE); CC BY-NC-SA 4.0 (model weights)
Last verified

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