by Seq2Study

BoltzGen

Generative model for binder design across protein and non-protein targets.

Boltz team (MIT CSAIL and collaborators)

What it does

Generative binder design against protein and non-protein targets. Input: target (protein, nucleic acid or small molecule) plus binding-site spec in YAML; output: designed binder backbones and sequences with self-consistency/refolding metrics.

Commercial use

Unverified

Licence as writtenMIT License

The repo LICENSE is MIT, covering the code. The README documents automatic download of ~6 GB Boltz weights plus ESMFold2 weights but makes no license statement for those weights, so weight terms are unverified.

We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.

Is commercial use free of charge?

Free for commercial use

No fee: code is MIT and the weights download automatically. The weights' own terms are not published, so 'free' here describes price, not a settled right to use them commercially.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Reach for it when you want a newer generative binder designer with built-in refolding metrics. Large download (~40 GB with ESMFold2) and needs a recent CUDA driver; very little independent wet-lab replication published yet.

Facts

Maker
Boltz team (MIT CSAIL and collaborators)
Cost for commercial use
Free for commercial use
Compute
Heavy GPU
Open weights
Yes
Licence
MIT License
Last verified

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