by Seq2Study

RFdiffusion

Diffusion model that generates protein backbones, including binders to a target.

Institute for Protein Design, University of Washington (RosettaCommons)

What it does

Generates protein backbones. Input: a target structure (PDB) with hotspot residues, or just a length/symmetry spec; output: backbone-only PDBs (no sequence) for de novo binders, scaffolds or motif grafts. You then run inverse folding (ProteinMPNN) and a structure predictor to filter.

Commercial use

Commercial use OK

Licence as writtenBSD License (as titled in the repo LICENSE file)

The LICENSE text states it covers both source code and the model weights referenced in the README; it is a permissive BSD-style license with no field-of-use restriction.

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Is commercial use free of charge?

Free for commercial use

Nothing to pay: the licence read at the source grants commercial use with no fee, and the code and weights are public downloads. You still pay for your own compute.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Default starting point for de novo backbone generation and target-conditioned binder scaffolds. Output needs sequence design (ProteinMPNN) and in-silico filtering; raw success rates per design are low, so expect to order many variants.

Facts

Maker
Institute for Protein Design, University of Washington (RosettaCommons)
Cost for commercial use
Free for commercial use
Compute
Single GPU
Open weights
Yes
Licence
BSD License (as titled in the repo LICENSE file)
Last verified

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