by Seq2Study

RFdiffusion2

Atom-level successor to RFdiffusion, aimed at enzyme and motif scaffolding.

Institute for Protein Design, University of Washington (RosettaCommons)

What it does

Generates backbones around an atomic motif without having to specify its indices. Input: a set of catalytic/functional atoms or a target site; output: backbone PDBs scaffolding that geometry, which you then sequence-design (LigandMPNN) and refold. Inference only in this release.

Commercial use

Unverified

Licence as writtenBSD 3-Clause License (code); no licence stated for the downloaded weights

The repo LICENSE.md is BSD 3-Clause (2025, Institute for Protein Design) and mentions only source and binary forms; the README's setup step downloads large model weight files and containers with no licence statement of their own, so the weights' commercial terms are unverified. The README also marks the release 'under construction'.

We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.

Is commercial use free of charge?

Cost unverified

Nothing is charged for the download. Whether a company may use the weights at all is unsettled, so no price can be stated.

Price and rights are separate: this panel is about money, the panel above is about permission.

When to use it

Reach for it over RFdiffusion v1 when the design problem is an atom-level site (enzyme active site, metal or ligand geometry) rather than a plain binder. Early release, inference only, and the weight licence question is unresolved - for commercial work that matters.

Facts

Maker
Institute for Protein Design, University of Washington (RosettaCommons)
Cost for commercial use
Cost unverified
Compute
Heavy GPU
Open weights
Yes
Licence
BSD 3-Clause License (code); no licence stated for the downloaded weights
Last verified

Other de novo binder and protein design tools